, 2006; Sawaya and Kraut, 1997; determine one—figure complement 1), we predicted the mutational landscape of DHFR to be constrained from the necessity to adopt these different conformations. In addition, prior do the job experienced advised DHFR is impacted by mobile constraints including protein high quality Command (Bershtein et al., 2013) along with the Develop-up of a harmful metabolic intermediate (Schober et al., 2019). We that's why predicted deep mutational scanning to reveal a extremely constrained mutational landscape for DHFR that may contrast with the mutational tolerance observed in other methods.
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The placement of your DHFR gene is stated in parenthesis in the very first column. Expression values corresponds to your cell pressure while in the column heading.
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(2020) Altered expression of a quality Handle protease in E. coli reshapes the in vivo mutational landscape of the model enzyme